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Asbestos is a material that was once used extensively in construction.One risk from working in a building that contains asbestos is the development of asbestosis.The asbestos fibers can be inhaled.Cells will phagocytose the foreign material but are unable to degrade it.As a result,asbestos fibers build up in which of the following intracellular organelles?


A) mitochondria
B) nucleus
C) peroxisomes
D) lysosomes

E) B) and C)
F) A) and B)

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How is the structure of kinesin related to its function?


A) Kinesin has two intertwined polypeptides that make up the stalk and enable it to contract and shorten.
B) Kinesin has a tail region that binds to vesicles and two heads that can attach to microtubules.
C) The kinesin tail has an ATP binding site to fuel its activities.
D) Kinesin has two heads to attach to the vesicle being moved,and a tail region that attaches to microtubules.

E) A) and B)
F) B) and D)

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B

Why are lysosomes considered part of the endomembrane system?


A) They deposit end-products of digestion in the endoplasmic reticulum.
B) They facilitate movement between stacks of the Golgi.
C) They are formed from products synthesized by the endoplasmic reticulum and processed by the Golgi.
D) Lysosomes are not part of the endomembrane system.

E) A) and B)
F) None of the above

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As part of our immune system,neutrophil cells engulf micro-organisms or foreign particles.The process by which the neutrophil does this is known as


A) exocytosis.
B) pinocytosis.
C) phagocytosis.
D) receptor-mediated endocytosis.

E) All of the above
F) A) and C)

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Amoeba move by crawling over a surface (amoeboid movement) .Which one of the following processes is part of amoeboid movement?


A) polymerization or extension of actin filaments to form bulges in the plasma membrane
B) setting up microtubule extensions that vesicles can follow in the movement of cytoplasm
C) reinforcing the pseudopod with intermediate filaments

D) None of the above
E) All of the above

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Motor proteins require energy in the form of ATP.ATP hydrolysis results in a conformational change that allows the protein to move along microtubular tracks (pathways) .What structural component of the motor protein contains the ATP binding site and,therefore,changes shape to enable movement?


A) the portion of the molecule that binds to the vesicle being transported
B) the stalk
C) the portion of the molecule that binds to the microtubular track along which the vesicle is being transported
D) a location midway between the vesicle binding site and the portion of the molecule that binds to microtubular tracks

E) A) and B)
F) A) and C)

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Which of the following organelles is involved in the oxidation of fatty acids or ethanol?


A) Golgi apparatus
B) Peroxisomes
C) Mitochondria
D) Rough endoplasmic reticulum

E) A) and B)
F) A) and C)

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What is the function of the nuclear pore complex?


A) It regulates movement of materials across the nuclear envelope.
B) It assembles ribosomes from raw materials that are synthesized in the nucleus.
C) It synthesizes components of the endomembrane system.
D) It synthesizes and repairs DNA.

E) A) and C)
F) A) and B)

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Which of the following is a basic structural difference between plant cells and animal cells?


A) Plant cells contain chloroplasts,but animal cells do not.
B) Animal cells contain lysosomes,but plant cells do not.
C) Plants have cell walls,and animal cells do not.
D) The cell wall plays a major role in determining plant cell shape,but the cytoskeleton plays a major role in determining animal cell shape.
E) All of the above apply.

F) All of the above
G) B) and D)

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One function of peroxisomes is alcohol detoxification.In which of the following locations would you expect to find large quantities of peroxisomes?


A) in liver tissue of people who drink large quantities of alcohol
B) in the stomach of people who drink large quantities of alcohol
C) in liver tissue of people who consume high-fat diets
D) in heart muscle of all people

E) C) and D)
F) B) and C)

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You are studying an organism and note that its proteins fail to be glycosylated.A deficiency in which of the following organelles is likely the cause?


A) Golgi apparatus
B) Peroxisomes
C) Mitochondria
D) Rough endoplasmic reticulum

E) B) and C)
F) All of the above

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Eukaryotic cells manufacture cytoskeletal proteins that help to maintain the cells' shapes and functions.What would you predict about these proteins?


A) They would initially contain signal sequences that would allow their entrance into the endoplasmic reticulum.
B) They would be manufactured on free ribosomes in the cytoplasm.
C) They would be glycosylated in the Golgi apparatus.
D) They might travel to the nucleus in a transport vesicle with a specific zip code.

E) None of the above
F) B) and D)

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What is the most likely role of a cell that contains an extensive smooth ER?


A) It plays a role in storage.
B) It synthesizes large quantities of lipids.
C) It actively exports protein molecules.
D) It plays a role in immune function.

E) A) and D)
F) All of the above

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What can you infer about high-molecular-weight proteins that cannot be transported into the nucleus?


A) They are foreign proteins.
B) They lack nuclear localization signals (NLS) .
C) They are defective proteins.
D) They have been tagged for destruction.

E) B) and D)
F) A) and B)

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Which of the following cytoskeletal proteins are important in changing cell shape or location (any type of cell movement) ?


A) Microfilaments are the only cytoskeletal proteins important in cell movement.
B) Microfilaments and myosin are among the cytoskeletal proteins important in cell movement.
C) Microfilaments,microtubules,and intermediate filaments are equally important in cell movement.
D) Intermediate filaments are the only cytoskeletal proteins important in cell movement.

E) A) and D)
F) C) and D)

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Actin filaments have polarity.This means that the two ends can be identified due to structural differences.The plus end is the end to which subunits are added more rapidly or the end of polymerization.Which of the following would enable you to identify the plus end of actin filaments?


A) Add radio labeled actin subunits to a mixture of actin filaments in which conditions are favorable for polymerization.
B) Add radiolabeled actin subunits to a mixture of actin filaments in which conditions favor depolymerization.
C) Determine the ionic charge of the ends of the actin filaments.

D) B) and C)
E) All of the above

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Mitochondrial DNA codes for about 13 proteins (depending on the species of organism) .These 13 proteins account for a small proportion of the proteins present in mitochondria.The remaining proteins are coded for by nuclear DNA.What is the most likely explanation for how these proteins find their way to the mitochondria?


A) signal sequences
B) random transport vesicles
C) attachment of ribosomes to outer mitochondrial pores and direct deposition into the inner mitochondrial compartment
D) mRNAs that are manufactured in the nucleus,but translated by mitochondrial ribosomes

E) All of the above
F) A) and D)

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A

What is the function of keratin,an important intermediate filament?


A) imparts impermeability to the skin and the ability to withstand mechanical stress
B) reinforces moveable joints
C) enables the heart to contract as a unit
D) provides nutrients to neural cells of the brain and spinal cord

E) B) and D)
F) None of the above

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To what does the 9 + 2 arrangement of microtubules,typical of cilia and eukaryotic flagella,refer?


A) the arrangement of dynein arms with respect to each microtubule
B) the arrangement of microtubules within the axoneme
C) the length of the structures
D) the relationship between the basal body and the axoneme

E) B) and C)
F) B) and D)

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B

Which of the following organelles contains receptors for the products of the rough endoplasmic reticulum?


A) the smooth endoplasmic reticulum
B) the lysosomes
C) the mitochondria
D) the peroxisomes

E) B) and C)
F) A) and D)

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