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The monomer subunit of immunoglobulin molecules has all the following, except


A) two identical heavy polypeptide chains.
B) two identical light polypeptide chains.
C) disulfide bonds between polypeptide chains.
D) four antigen binding sites.
E) a variable and constant region on each polypeptide chain.

F) A) and B)
G) A) and C)

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The immunoglobulin class that is the only one capable of crossing the placenta is


A) IgA.
B) IgD.
C) IgE.
D) IgG.
E) IgM.

F) B) and C)
G) D) and E)

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All of the following are advantages of attenuated vaccines over inactivated vaccines except


A) they confer longer lasting protection.
B) they produce infection but not disease.
C) they can mutate back to a virulent strain.
D) they require fewer boosters.
E) they require smaller doses.

F) B) and C)
G) B) and D)

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Properties of effective antigens include all the following, except


A) foreign to the immune system.
B) molecular complexity.
C) large molecules with a minimum molecular weight of 1,000.
D) large polymers made up of repeating subunits.
E) cells or large, complex molecules.

F) All of the above
G) B) and C)

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All of the following are characteristics of IgM, except


A) it has 10 antigen binding sites.
B) it contains a central J chain.
C) it is the first class synthesized by a plasma cell.
D) it can fix complement.
E) it is a dimer.

F) C) and D)
G) All of the above

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Cell surface markers involved in immune reactions


A) are the result of genetic expression.
B) function in recognition of self molecules.
C) receive and transmit chemical messages among other cells of the system.
D) aid in cellular development.
E) all of the choices are correct.

F) A) and C)
G) All of the above

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Antibody molecules circulate in lymph, blood, and tissue fluids.

A) True
B) False

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Which immunoglobulin class/es can fix complement?


A) IgM only
B) IgG only
C) IgD only
D) IgM and IgG
E) IgE and IgA

F) A) and E)
G) All of the above

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Cytotoxic T cells


A) stimulate B cell proliferation.
B) lack specificity for a target cell.
C) secrete granzymes and perforins that damage target cells.
D) secrete interleukin-2 to stimulate B and T cells.
E) All of the choices are correct.

F) C) and D)
G) C) and E)

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Certain body sites contain sequestered molecules, called _____ that escaped assessment during development of immune tolerance and are mistaken as foreign.

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Which type of cell is severely depressed in AIDS patients?


A) Cytotoxic T cells
B) Helper T cells
C) B cells
D) Plasma cells
E) Suppressor T cells

F) A) and C)
G) B) and D)

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Which cells direct involvement are required for cell-mediated immunities?


A) T-cells
B) B-cells
C) Bacterial cells
D) Viral components

E) A) and D)
F) A) and C)

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Which sequence of events is correct for a specific immune response?


A) Lymphocyte development, presentation of antigens, antibody production, challenge of B cells.
B) Lymphocyte development, challenge of B cells, antibody production, presentation of antigens.
C) Lymphocyte development, presentation of antigens, B cell challenge, antibody production.
D) Antibody production, lymphocyte production, B cell challenge, presentation of antigens.

E) C) and D)
F) A) and D)

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A hybridoma results from the fusion of a myeloma cell with a normal _____ cell.

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Antibody molecules can act as enzyme to directly destroy an antigen.

A) True
B) False

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Which process involves antibodies coating microorganisms in order to facilitate phagocytosis?


A) Neutralization
B) Opsonization
C) Complement fixation
D) Agglutination
E) Anamnestic response

F) A) and D)
G) C) and E)

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During presentation of APC-bound antigen, macrophages secrete the cytokine, _____, that activates T helper cells.

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Which process involves antibodies covering surface receptors on a virus or toxin molecule thereby disrupting their activity?


A) Neutralization
B) Opsonization
C) Complement fixation
D) Agglutination
E) Anamnestic response

F) A) and C)
G) None of the above

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When antiserum is subjected to electrophoresis, the gamma globulin band contains mostly


A) IgM.
B) IgA.
C) IgD.
D) IgE.
E) IgG.

F) None of the above
G) D) and E)

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Immune sera is produced in horses for all the following except


A) diphtheria.
B) botulism.
C) snake bites.
D) chickenpox.
E) spider bites.

F) A) and D)
G) A) and B)

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