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  Figure 7.1 -Carbon skeletons for amino acid biosynthesis are supplied by intermediates of the citric acid cycle. Which intermediate could directly supply the carbon skeleton for synthesis of a five-carbon amino acid (see Figure 7.1) ? A)  succinate B)  malate C)  citrate D)  α-ketoglutarate E)  isocitrate Figure 7.1 -Carbon skeletons for amino acid biosynthesis are supplied by intermediates of the citric acid cycle. Which intermediate could directly supply the carbon skeleton for synthesis of a five-carbon amino acid (see Figure 7.1) ?


A) succinate
B) malate
C) citrate
D) α-ketoglutarate
E) isocitrate

F) A) and B)
G) A) and C)

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The complete oxidation of glucose (C₆H₁₂O₆) to carbon dioxide and water in aerobic respiration consumes how many molecules of oxygen (O₂) ?


A) 1
B) 3
C) 6
D) 12
E) 36

F) B) and E)
G) A) and C)

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Substrate-level phosphorylation accounts for approximately what percentage of the ATP formed by the reactions of glycolysis?


A) 0%
B) 2%
C) 10%
D) 38%
E) 100%

F) B) and D)
G) All of the above

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  Figure 7.2 -What happens at the end of the chain in Figure 7.2? A)  Two electrons combine with a proton and a molecule of NAD+. B)  Two electrons combine with a molecule of oxygen and two hydrogen atoms. C)  Four electrons combine with a molecule of oxygen and four protons. D)  Four electrons combine with four hydrogen and two oxygen atoms. E)  One electron combines with a molecule of oxygen and a hydrogen atom. Figure 7.2 -What happens at the end of the chain in Figure 7.2?


A) Two electrons combine with a proton and a molecule of NAD+.
B) Two electrons combine with a molecule of oxygen and two hydrogen atoms.
C) Four electrons combine with a molecule of oxygen and four protons.
D) Four electrons combine with four hydrogen and two oxygen atoms.
E) One electron combines with a molecule of oxygen and a hydrogen atom.

F) A) and B)
G) A) and E)

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Which kind of metabolic poison would most directly interfere with glycolysis?


A) an agent that reacts with oxygen and depletes its concentration in the cell
B) an agent that binds to pyruvate and inactivates it
C) an agent that closely mimics the structure of glucose but is not metabolized
D) an agent that reacts with NADH and oxidizes it to NAD+
E) an agent that blocks the passage of electrons along the electron transport chain

F) C) and D)
G) A) and C)

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What fraction of the carbon dioxide exhaled by animals is generated by the oxidation of pyruvate to acetyl CoA, if glucose is the sole energy source?


A) 1/6
B) 1/3
C) 1/2
D) 2/3
E) all of it

F) All of the above
G) C) and D)

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Yeast cells grown anaerobically can obtain energy by fermentation, which results in the production of


A) ATP, NADH, and pyruvate.
B) ATP and lactate.
C) ATP, CO₂, and lactate.
D) ATP, CO₂, and ethanol.
E) ATP, CO₂, and acetyl CoA.

F) A) and C)
G) B) and E)

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Which of the following produces the most ATP when glucose (C₆H₁₂O₆) is completely oxidized to carbon dioxide (CO₂) and water?


A) glycolysis
B) fermentation
C) oxidation of pyruvate to acetyl CoA
D) citric acid cycle
E) oxidative phosphorylation (chemiosmosis)

F) A) and D)
G) A) and E)

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Which metabolic pathway requires a proton gradient?


A) the oxidation of pyruvate to acetyl CoA
B) the citric acid cycle
C) oxidative phosphorylation
D) glycolysis
E) fermentation

F) B) and E)
G) None of the above

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When an electron is transferred to a more electronegative atom


A) it loses potential energy.
B) it gains potential energy.
C) it gains kinetic energy.
D) it oxidizes the more electronegative atom.

E) All of the above
F) A) and D)

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The ATP made during fermentation is generated by which of the following?


A) the electron transport chain
B) substrate-level phosphorylation
C) chemiosmosis
D) oxidative phosphorylation
E) aerobic respiration

F) B) and E)
G) A) and B)

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When electrons flow along the electron transport chains of mitochondria, which of the following changes occurs?


A) The pH of the matrix increases.
B) ATP synthase pumps protons by active transport.
C) The electrons gain free energy.
D) NAD+ is oxidized.

E) B) and D)
F) A) and D)

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In liver cells, the inner mitochondrial membranes are about five times the area of the outer mitochondrial membranes. What purpose must this serve?


A) It increases the surface area for glycolysis.
B) It increases the surface area for the citric acid cycle.
C) It increases the surface area for oxidative phosphorylation.
D) It increases the surface area for substrate-level phosphorylation.

E) A) and D)
F) C) and D)

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  Figure 7.2 -Which of the protein complexes labeled with Roman numerals in Figure 7.2 will transfer electrons to O₂? A)  complex I B)  complex II C)  complex III D)  complex IV E)  All of the complexes can transfer electrons to O₂. Figure 7.2 -Which of the protein complexes labeled with Roman numerals in Figure 7.2 will transfer electrons to O₂?


A) complex I
B) complex II
C) complex III
D) complex IV
E) All of the complexes can transfer electrons to O₂.

F) A) and B)
G) A) and C)

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When an individual is exercising heavily and the muscle becomes oxygen-deprived, muscle cells convert pyruvate to lactate. What happens to the lactate in skeletal muscle cells?


A) It is reduced and converted back to pyruvate in muscle cells.
B) It is oxidized to CO₂ and water.
C) It is taken to the liver and converted back to pyruvate.
D) It oxidizes FADH₂ to FAD+.
E) It is converted to alcohol.

F) B) and D)
G) A) and B)

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The immediate energy source that drives ATP synthesis by ATP synthase during oxidative phosphorylation is the


A) oxidation of glucose and other organic compounds.
B) flow of electrons down the electron transport chain.
C) H+ concentration gradient across the membrane holding ATP synthase.
D) transfer of phosphate to ADP.

E) All of the above
F) A) and B)

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In alcohol fermentation, NAD+ is regenerated from NADH by


A) oxidation of ethanol to acetaldehyde.
B) oxidation of pyruvate to acetyl CoA.
C) reduction of pyruvate to lactate.
D) reduction of acetaldehyde to ethanol.
E) reduction of acetyl CoA to ethanol.

F) A) and E)
G) C) and D)

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Why are carbohydrates and fats considered high-energy foods?


A) They have a lot of oxygen atoms.
B) They have few nitrogen atoms.
C) They have a large number of electrons associated with hydrogen.
D) They have a lot of carbon atoms bound together by single covalent bonds.
E) They are easily reduced.

F) A) and B)
G) A) and C)

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Which catabolic processes may have been used by cells on ancient Earth before free oxygen became available?


A) only glycolysis and fermentation
B) only glycolysis and the citric acid cycle
C) only glycolysis and pyruvate oxidation
D) only oxidative phosphorylation, using an electron acceptor other than oxygen
E) glycolysis, pyruvate oxidation, the citric acid cycle, and oxidative phosphorylation, using an electron acceptor other than oxygen

F) A) and B)
G) C) and D)

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When hydrogen ions are pumped from the mitochondrial matrix across the inner membrane and into the intermembrane space, the result is


A) the formation of ATP.
B) the reduction of NAD+.
C) a decrease in the pH of the mitochondrial matrix.
D) the creation of a proton-motive force.

E) A) and D)
F) A) and C)

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